Matteo Levantino

Matteo Levantino
Position:Assistant Professor 
Affiliation:Department of Physics and Chemistry
University of Palermo
Via Archirafi 36
I-90123 Palermo
Tel: (+39) 091-238-91729

Research Statement

Current research focuses on elucidating the characteristic features of proteins energy landscape. Time-resolved optical spectroscopy and wide-angle X-ray scattering are used to probe the dynamics of functionally relevant conformational changes in proteins.

The relationship between protein motions and the dynamics of the surrounding solvent is investigated with different experimental techniques (magnetic resonance, differential scanning calorimetry, dielectric spectroscopy, etc.) over a wide range of experimental parameters such as temperature and/or viscosity.

Current Projects

Selected Publications

  1. Levantino M, Spilotros A, Cammarata M, Schiro G, Ardiccioni C, Vallone B, Brunori M, Cupane A

    The MWC model accounts for the quaternary transition dynamics in wild type and a recombinant mutant human hemoglobin

    Proc. Natl. Acad. Sci. USA 109:14894-14899 (2012) [Abstract]
  2. Cammarata M, Levantino M, Wulff M, Cupane A

    Unveiling the time scale of the R-T transition in human hemoglobin

    J. Mol. Biol. 400:951-962 (2010). [Journal cover illustration] [Abstract]
  3. Cammarata M, Levantino M, Schotte F, Anfinrud PA, Ewald F, Choi J, Cupane A, Wulff M, Ihee H

    Tracking the structural dynamics of proteins in solution using time-resolved wide-angle X-ray scattering

    Nature Methods 5:881-886 (2008). [Journal cover illustration] [Abstract]
  4. Levantino M, Huang Q, Cupane A, Laberge M, Hagarman A, Schweitzer-Stenner R

    The importance of vibronic perturbations in ferrocytochrome c spectra: a reevaluation of spectral properties based on low-temperature optical absorption, resonance Raman, and molecular-dynamics simulations

    J. Chem. Phys. 123:054508(1)-054508(12) (2005). [Abstract]
  5. Levantino M, Cupane A, Zimanyi L, Ormos P

    Different relaxations in myoglobin after photolysis

    Proc. Natl. Acad. Sci. USA 101:14402-14407 (2004). [Abstract]
  6. Levantino M, Cupane A, Zimanyi L

    Quaternary structure dependence of kinetic hole burning and conformational substates interconversion in hemoglobin

    Biochemistry 42:4499-4505 (2003). [Abstract]
  7. Cupane A, Levantino M, Santangelo MG

    Near-infrared spectra of water confined in silica hydrogels in the temperature interval 365-5K

    J. Phys. Chem. B 106:11323-11328 (2002). [Abstract]